Please right-click on the Downloads folder and click Properties.
Select the Customize tab.
In the “Optimize the folder for:” dropdown, select “Documents”.
Click “Apply”.
Now, select “General Items” in the dropdown.
Click OK.
If that doesn’t fix the issue, one of the recently downloaded files in that folder may be causing the issue.
Moving the files to a subfolder should help. To do so, open Command Prompt and run these commands:
md "%userprofile%\downloads\Temp"
move "%userprofile%\downloads\*.*" "%userprofile%\downloads\temp\"
Check to see if the Downloads folder opens correctly. If so, the next step is to determine the offending file (which is now located in the Downloads\Temp folder.)